女医生凯特（桑德拉•布洛克 饰）因为工作繁忙，搬离了郊外的河边小屋。临走时她在信箱里放了一封信，希望下一位住客能帮忙处理信件。不久，她来到了旧址，发现信箱里面有一封来自建筑师亚历克斯（基努•里维斯 饰...

Ethan is a young, shy and rather reserved designer who has suffered from insomnia for many years due to his terrible nightmares. Believing he has a personality disorder he decides to see a therapist to solve his problem,…

三個平日作惡多端的混混因為搶了一台露營車，而遇上一對逃亡中的母子，又被牽扯進一樁神祕的人體改造疫苗計劃，途中加入了瘋狂殺手與退休警察，大家一起往地獄直直撞去。